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Residual solvents are trace level impurities of organic volatile compounds used or produced in manufacturing active substances, excipients and pharmaceutical products. The international conference on Harmonization (ICH) Q3C, United State pharmacopoeia (USP) method 467, and the European Pharmacopoeia 2.4.24 have set guidelines to identify and quantify these solvents in pharmaceutical products to address the risk on human health.

GC-HS technique is used in identification and quantification of residual solvents in pharmaceutical products as per national and international Pharmacopoeia.

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