Buy Curcumin, C.I. 75300 (458-37-7) MF: C21H20O6 | MW: 368.38. Get High Quality Curcumin, C.I. 75300 (458-37-7) from TriStains at Dawnscientific.com
Curcumin is a polyphenolic compound and belongs to the class of curcuminoids. Its chemical structure consists of two aromatic rings connected by a seven-carbon linker with functional groups, including phenols and keto-enol tautomers.
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Applications:
Analytical Chemistry: Curcumin is used as a reagent and a probe in analytical chemistry. Its ability to react with metal ions, such as aluminum, iron, and copper, makes it useful for colorimetric detection and quantification of these metals in various samples.Fluorescent Probe: Curcumin exhibits inherent fluorescence properties, making it useful as a fluorescent probe. It can be employed in fluorescence microscopy and imaging techniques to visualize cellular structures, study biological processes, and detect specific biomolecules.Chemical Sensors: Curcumin has been explored as a sensing material for developing chemical sensors. Its interactions with certain analytes can lead to changes in its fluorescence or absorbance properties, allowing for the detection and measurement of analytes in fields like environmental monitoring and biomedical diagnostics.Polymer Stabilizer and Dye: Curcumin can be used as a stabilizer in polymers, particularly for polymeric materials susceptible to degradation by heat, UV light, or oxidation. It also serves as a natural dye, providing a yellow to orange color to polymeric materials and coatings.Drug Delivery Systems: The chemical structure and properties of curcumin make it suitable for incorporation into drug delivery systems. Curcumin can be used as a carrier or encapsulating agent for delivering therapeutic agents, including drugs and nanoparticles, to specific target sites in the body.
Curcumin, C.I. 75300
Curcumin, C.I. 75300 | 458-37-7 | C21H20O6 | M.W 368.38 | Dawn Scientific. Yellow-orange dye with diverse biological targets. Explore its applications.
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ADDITIONAL INFORMATION
Application | Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP. |
CAS Number | 458-37-7 |
Purity | ≥95% |
Molecular Weight | 368.38 |
Molecular Formula | C21H20O6 |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Refer to Certificate of Analysis for lot specific data (including water content).
Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.
TECHNICAL INFORMATION
Appearance : | Powder |
Physical State : | Solid |
Solubility : | Soluble in water (1 mg/ml), and ethanol (1%). Insoluble in acetone. |
Derived From : | Turmeric rhizome |
Solubility : | Soluble in DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform. Insoluble in ethanol. |
Storage : | Store at room temperature |
Melting Point : | 170-175° C |
Boiling Point : | ~591.4° C at 760 mmHg (Predicted) |
Density : | ~1.3 g/cm3 (Predicted) |
Refractive Index : | n20D 1.42 |
IC50 : | 5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM |
SAFETY INFORMATION
WGK Germany : | 3 |
PubChem CID : |
969516
|
RTECS : |
MI5230000
|
Merck Index : |
14: 2673
|
MDL Number : |
MFCD00008365
|
EC Number : |
207-280-5
|
Beilstein Registry : |
2306965
|
SMILES : |
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
|
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